Post 4.01 patch
I just did 4 or 5 quests. The chat parts were generally very buggy. In order to advance to the next message in the conversation (when the NPC tells you several things in a row without a reply needed from the player) sometimes just needed to wait for them to speak again, other times I needed to click on them. Clicking too soon always ended up with the NPC saying "I have nothing more to offer you" or "Can't you see I'm busy" (paraphrased)
A couple times the linearity of the messages I received was messed up. The NPC would repeat something they already said, and not even the thing they just said, but something from a couple messages ago, and then they'd continue on from there, like I was sent back a couple events in the quest.
Another time I was asked by the NPC to perform a task to retrieve specific items and report back. The NPC jumped ahead in the events and started behaving as if I had brought the items although I did not, which allowed me to finish the quest without meeting all requirements.
Regarding chat and responding to NPCs - At first I wasn't using /ch l or /l and I was in /ch o, the NPC would still respond accordingly. The things I typed would still end up in /ch o as well. (Was asked if I was ok by a concerned player who saw me babbling). One time I believe (could be incorrect) that when I responded "yes" to NPC in /ch o, the NPC responded, but my chat message did not actually relay to the chat room.